Liverpool vs Atletico Madrid Prediction: 28/1 Bet Builder, Odds & Team News

Liverpool host Atletico Madrid at Anfield on Wednesday in the first gameweek of the 2026/27 Champions League, with kick-off set for 8pm.

The two sides last met a year ago, when Liverpool produced a dramatic late comeback to claim a 3-2 victory thanks to a goal in stoppage time. Fast-forward to 2026 and the Reds, under Andoni Iraola, will be hoping for another three points in front of their own fans.

Read on for the best Liverpool vs Atletico Madrid predictions, bet builder tips, odds, and team news.

Alexander Isak is still waiting for his first Champions League goal in a Liverpool shirt, but his early-season form suggests it could be coming soon.

After an injury-hit first campaign with the Reds, Isak managed just three Premier League goals last season; a tally he's already matched after just three games this term.

The Swedish striker opened his account with a goal in the 2-2 draw against Nottingham Forest before taking his tally to three with a brace in Liverpool’s 2-0 victory at Ipswich last time out.

That makes Isak an appealing anytime goalscorer pick at 6/4 with bet365, against a wounded Atletico Madrid arriving in Merseyside on the back of a heavy 3-0 defeat to Athletic Bilbao.

We’ve put together a 28/1 bet builder with bet365, requiring Liverpool to score two or more goals, Cody Gakpo to register an assist, and Milos Kerkez to be shown a card.

Liverpool have scored two goals in each of their three Premier League games this season, while they’ve also found the net at least twice in each of their last four meetings with Atletico Madrid.

Cody Gakpo was heavily linked with a summer move to Manchester City, but a transfer failed to materialise. Despite this, the winger has made an impressive start to the campaign, scoring once and providing three assists across his opening three games.

Gakpo’s teammate Milos Kerkez is no stranger to picking up bookings. The full-back has already been carded twice this season and could be one to keep an eye on when he lines up on Wednesday night.

It’s worth remembering that bet365’s ‘Sub On Play On’ feature applies to this bet builder. So, if Gakpo and/or Kerkez are substituted, then the bet rolls onto their replacement.

Liverpool vs Atletico Madrid Team News

Bradley Barcola will hope to get his first start for Liverpool after coming off the bench in the 2-0 win over Ipswich.

The hosts will be without Joe Gomez, Conor Bradley, Hugo Ekitike, and Giovanni Leoni.

As for Atletico, Alexander Sorloth is injured and Arnau Ortiz is suspended. 

Liverpool vs Atletico Madrid Starting Lineups