Rams vs. 49ers Picks & Best Bets 12th Dec 2024: NFL Week 15 Prediction, Betting Odds, Player Props & Trends

The San Francisco 49ers will host the Los Angeles Rams in NFL action on Thursday at Levi's Stadium, starting at 8:15 p.m. ET.
We've conducted 10,000 simulations of Thursday's NFL matchup using advanced AI technology to determine the best Rams vs. 49ers bets, player props and predictions.
Based on these simulations, we predict that the 49ers will likely beat the Rams with a projected final score of 25-22.
To maximize the value of predictions like this, we continuously monitor the best odds for each market. This ensures that the sportsbooks listed below are currently offering the biggest payouts for the specified plays.
Our Rams vs. 49ers Betting Picks & Predictions
Today's Rams vs. 49ers picks fuse the power of AI, data and analytics to generate NFL picks that are free from the emotional biases typical of human-made picks.
Rams vs. 49ers Game Information
- Game Date: Thursday, December 12th, 2024
- Game Time: 8:15 p.m. ET
- Location: Levi's Stadium
- Spread: Rams +2.5 / 49ers -2.5
- Moneyline: Rams +134 / 49ers -150
- Scoring Total: Over/Under 49 Points (-110/-110)
49ers -2.5 @ -125 via BetMGM
- According to our simulations, the 49ers have a 56% chance of covering the spread, while the Rams have a probability of 44%.
- BetMGM offers the best odds for this bet at -125.
Total Points Under 49 @ -110 via BetMGM
- The over/under for total points scored is set at 49 at BetMGM, which offers the best odds for the under at -110.
- Our analysis indicates a 51% probability that the total will stay under 49 points.
Rams vs. 49ers Moneyline Odds
The sportsbooks have released the moneyline odds for this matchup, with the Los Angeles Rams at +134 via FanDuel Sportsbook, whilst the San Francisco 49ers are available at -150 with BetMGM.
According to the model, the 49ers are favored to win this game, with our projections assigning them a 59% chance of coming out on top.
Additionally, the 49ers present the best betting value, with the odds of -150 available at BetMGM making it our recommended moneyline bet.
Our Player Prop Picks for Rams vs. 49ers
Here, we have outlined the projected player stats for the top offensive players on each team. We have then compared these projections to the odds and lines with the sportsbooks to produce NFL player props for Thursday's Rams vs. 49ers matchup.
Los Angeles Rams Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Kyren Williams | 84 yds | 53% |
Blake Corum | 26 yds | 19% |
Matthew Stafford | 7 yds | 11% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Puka Nacua | 90 yds | 42% |
Cooper Kupp | 74 yds | 38% |
Demarcus Robinson | 28 yds | 18% |
Demarcus Robinson Over 16.5 Receiving Yards (-120)
Pick | Operator | New Users | Odds |
---|---|---|---|
Demarcus Robinson Over 16.5 Receiving Yards | DraftKings Sportsbook | Get Offer | -120 |
- Our top prop bet for the Rams is for Demarcus Robinson to record over 16.5 receiving yards.
- Our analysis projects this prop to have a probability of 67.2%, giving us an edge of 12.7% on the -120 odds offered by DraftKings.
San Francisco 49ers Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Isaac Guerendo | 61 yds | 45% |
Patrick Taylor | 41 yds | 24% |
Brock Purdy | 12 yds | 20% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
George Kittle | 64 yds | 44% |
Jauan Jennings | 63 yds | 29% |
Deebo Samuel | 46 yds | 39% |
Brock Purdy Under 19.5 Rushing Yards (-115)
Pick | Operator | New Users | Odds |
---|---|---|---|
Brock Purdy Under 19.5 Rushing Yards | DraftKings Sportsbook | Get Offer | -115 |
- Our best prop bet for the 49ers is for Brock Purdy to record under 19.5 rushing yards.
- According to our analysis, this prop has a probability of 80.8%, providing an edge of 27.3% on the -115 odds offered by DraftKings.
These NFL player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.
Rams vs. 49ers Betting Trends
In addition to our NFL prop picks, we have compiled the best Rams vs. 49ers trends to enhance your research and betting strategy for this matchup.
Tutu Atwell Over 15.5 Receiving Yards
Tutu Atwell has recorded more than 15.5 receiving yards in 9 of his last 10 games (90% success rate). You can bet on him to record 16+ receiving yards again at odds of -110 (52% implied probability), available at Bet365.
Colby Parkinson Over 9.5 Receiving Yards
Colby Parkinson has had more than 9.5 receiving yards in 9 of his last 10 games (90%). You can place a bet on him to record over 9.5 receiving yards again at odds of -105 (51%), also available at Bet365.
Puka Nacua Over 87.5 Receiving Yards
Puka Nacua has had more than 87.5 receiving yards in 4 of his last 5 games (80%). You can wager on him to record over 87.5 receiving yards again at odds of -110 (52%), again available at Bet365.
Conclusion
At BettingOdds.com, we're backing Brock Purdy of the 49ers to record Rushing Yards 19.5 rushing yards, with an edge of 27.3% marking this as our top prop bet of the game. Additionally, we are placing a bet on the 49ers -2.5 to cover.
Beyond our Rams vs. 49ers predictions, we offer extensive NFL betting resources. These include the latest NFL betting odds and insightful NFL expert picks to elevate your betting game. Discover top picks with our NFL best bets and dive into our NFL expert insights. Plus, find the best odds and promotions with our guide to the best NFL betting sites.