Ohio State vs. Notre Dame Picks & Best Bets 20th Jan 2025: College Football Prediction and Betting Odds

Notre Dame will host Ohio State in college football action on Monday at Mercedes-Benz Stadium, starting at 7:30 p.m. ET.
We have conducted 10,000 simulations of Monday's college football matchup using advanced AI technology to reveal the best Ohio State vs. Notre Dame bets and predictions.
According to our predictions, Ohio State will likely beat Notre Dame with a projected final score of 26-21.
To maximize the value of predictions like this, we continuously source the best odds for each market. This means that the sportsbooks listed below are currently offering the biggest payouts for the specified plays.
Our Ohio State vs. Notre Dame Betting Picks & Predictions
Today's Ohio State vs. Notre Dame picks fuse the power of AI, stats and analytics to generate NCAAF picks that are free from the emotional biases often associated with human-made picks.
Ohio State vs. Notre Dame Game Information
- Game Date: Monday, January 20th, 2025
- Game Time: 7:30 p.m. ET
- Location: Mercedes-Benz Stadium
- Spread: Ohio State -8.5 / Notre Dame +8.5
- Moneyline: Ohio State -350 / Notre Dame +310
- Scoring Total: Over/Under 45.5 Points (-110/-110)
Notre Dame +8.5 @ -110 via BetMGM
- According to our simulations, Notre Dame has a 60% chance of covering the spread, while Ohio State has a probability of 40%.
- BetMGM offers odds of -110 for Notre Dame +8.5, providing a favorable 7.2% edge for them to cover.
Total Points Over 45.5 @ -110 via BetMGM
- The over/under for total points scored is set at 45.5 at BetMGM, which offers the best odds for the over at -110.
- Our analysis shows a 55% probability of the 45.5-point total going over, providing an edge of 2.5%.
Ohio State vs. Notre Dame Moneyline Odds
The sportsbooks have released the moneyline odds for this matchup, with Ohio State at -350 via FanDuel Sportsbook, whilst the Notre Dame Notre Dame are available at +310 with BetMGM.
According to the model, Ohio State is favored to win this game, with our projections assigning them a 65% chance of prevailing.
Even though Ohio State is more likely to win, BetMGM offers +310 odds on the Notre Dame moneyline, providing an edge of 11.1%. This makes it our recommended moneyline bet.
Ohio State vs. Notre Dame Betting Trends
In addition to our College Football prop picks, we have sourced the best Ohio State vs. Notre Dame trends to enhance your research and betting strategy for this matchup.
Jadarian Price Over 5.5 Rushing Attempts
Jadarian Price has recorded more than 5.5 rushing attempts in 7 of his last 7 appearances (100% success rate). You can wager on him to go over 5.5 rushing attempts again at odds of -105 (51% implied probability), available at Bet365.
Kris Mitchell Over 5.5 Receiving Yards
Kris Mitchell has had more than 5.5 receiving yards in 8 of his last 8 games (100%). You can make a bet that he'll record over 5.5 receiving yards again at odds of -115 (53%), also available at Bet365.
Jadarian Price Over 23.5 Rushing Yards
Jadarian Price has had more than 23.5 rushing yards in 6 of his last 7 appearances (86%). You can bet on him to record over 23.5 rushing yards again at odds of -112 (53%), available at FanDuel.
Conclusion
At BettingOdds.com, we're placing a bet on the Notre Dame +8.5 to cover the spread in this matchup. As for the head-to-head, Ohio State has a 65% chance of getting the win.
Beyond our Ohio State vs. Notre Dame predictions, we offer a wide range of College Football betting tools. These include the latest College Football odds and insightful College Football computer picks to elevate your betting game. Discover top picks with the College Football best bets today and dive into our College Football insights.