Patriots vs. 49ers Picks & Best Bets 29th Sep 2024: NFL Week 4 Prediction, Betting Odds, Player Props & Trends

The San Francisco 49ers will meet the New England Patriots in NFL action on Sunday at Levi's Stadium, starting at 4:05 p.m. ET.
We've performed 10,000 simulations of Sunday's NFL matchup using innovative AI technology to identify the best Patriots vs. 49ers bets, player props and predictions.
Based on these simulations, we predict that the 49ers will likely defeat the Patriots with a projected final score of 25-15.
To maximize the value of predictions like this, we continually monitor the most favorable odds for each market. This ensures that the sportsbooks listed below are currently offering the biggest payouts for the specified plays.
Our Patriots vs. 49ers Betting Picks & Predictions
Today's Patriots vs. 49ers picks combine the power of AI, stats and analytics to create NFL predictions that are free from the emotional biases typical of human-made picks.
Patriots vs. 49ers Game Information
- Game Date: Sunday, September 29th, 2024
- Game Time: 4:05 p.m. ET
- Location: Levi's Stadium
- Spread: Patriots +10.5 / 49ers -10.5
- Moneyline: Patriots +450 / 49ers -560
- Scoring Total: Over/Under 42.5 Points (-105/-112)
Patriots +10.5 @ -110 via BetMGM
- According to our simulations, the Patriots have a 54% chance of covering the spread, while the 49ers have a probability of 46%.
- BetMGM offers odds of -110 for the Patriots +10.5, presenting a favorable 1.2% edge for them to cover.
Total Points Under 42.5 @ -112 via DraftKings Sportsbook
- The over/under for total points scored is set at 42.5 at DraftKings Sportsbook, which offers the best odds for the under at -112.
- Our analysis shows a 54% chance of the 42.5-point total staying under, providing an edge of 1.6%.
Patriots vs. 49ers Moneyline Odds
The sportsbooks have released the moneyline odds for this matchup, with the New England Patriots at +450 via BetMGM, whilst the San Francisco 49ers are available at -560 with FanDuel Sportsbook.
According to the model, the 49ers are heavily favored to win this game, with our projections assigning them an 83% chance of prevailing.
Although the 49ers are more likely to win, BetMGM offers +450 odds on the Patriots moneyline, making it our recommended moneyline bet, as it represents the best value currently available.
Our Player Prop Picks for Patriots vs. 49ers
Here, we have outlined the projected player stats for the top offensive players on each team. We have then compared these projections to the odds and lines with the sportsbooks to produce NFL player props for Sunday's Patriots vs. 49ers matchup.
New England Patriots Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Rhamondre Stevenson | 66 yds | 40% |
Antonio Gibson | 25 yds | 23% |
Jacoby Brissett | 14 yds | 17% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
DeMario Douglas | 37 yds | 17% |
Hunter Henry | 32 yds | 21% |
Ja'Lynn Polk | 26 yds | 13% |
Antonio Gibson Over 18.5 Rushing Yards (-110)
Pick | Operator | New Users | Odds |
---|---|---|---|
Antonio Gibson Over 18.5 Rushing Yards | FanDuel Sportsbook | Get Offer | -110 |
- Our top prop bet for the Patriots is for Antonio Gibson to record over 18.5 rushing yards.
- Our analysis projects this prop to have a probability of 67.4%, providing an edge of 15.0% on the -110 odds offered by FanDuel.
San Francisco 49ers Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Jordan Mason | 83 yds | 54% |
Isaac Guerendo | 15 yds | 12% |
Deebo Samuel | 11 yds | 41% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Brandon Aiyuk | 68 yds | 38% |
Deebo Samuel | 62 yds | 41% |
George Kittle | 52 yds | 34% |
Jordan Mason Under 1.5 Receptions (+120)
Pick | Operator | New Users | Odds |
---|---|---|---|
Jordan Mason Under 1.5 Receptions | DraftKings Sportsbook | Get Offer | +120 |
- Our best prop bet for the 49ers is for Jordan Mason to record under 1.5 receptions.
- According to our analysis, this prop has a probability of 64.8%, providing an edge of 19.4% on the +120 odds offered by DraftKings.
These NFL player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.
Patriots vs. 49ers Betting Trends
In addition to our NFL prop picks, we have sourced the best Patriots vs. 49ers trends to enhance your research and betting strategy for this game.
Brock Purdy Over 6.5 Rushing Yards
Brock Purdy has recorded more than 6.5 rushing yards in 6 of his last 6 games (100% success rate). You can wager on him to record 7+ rushing yards again at odds of -105 (51% implied probability), available at FanDuel.
Kyle Juszczyk Over 11.5 Receiving Yards
Kyle Juszczyk has had more than 11.5 receiving yards in 5 of his last 6 appearances (83%). You can place a wager on him to record over 11.5 receiving yards again at odds of -110 (52%), available at Bet365.
Brock Purdy Over 249.5 Passing Yards
Brock Purdy has had more than 249.5 passing yards in 5 of his last 6 games (83%). You can wager on him to record over 249.5 passing yards again at odds of -110 (52%), again available at Bet365.
Conclusion
At BettingOdds.com, we're backing Jordan Mason of the 49ers to record Receptions 1.5 receptions, with an edge of 19.4% marking this as our top prop bet of the game. Additionally, we are betting on the Patriots +10.5 to cover.
In addition to our Patriots vs. 49ers predictions, we offer extensive NFL betting resources. These include the latest NFL odds and insightful NFL predictions to elevate your betting game. Discover top picks with our best NFL bets and dive into our NFL insights. Plus, find the best odds and promotions with our guide to the best online NFL betting sites.