Cardinals vs. Panthers Picks & Best Bets 22nd Dec 2024: NFL Week 16 Prediction, Betting Odds, Player Props & Trends

The Carolina Panthers will go up against the Arizona Cardinals in NFL action on Sunday at Bank of America Stadium, beginning at 1:00 p.m. ET.
We have run 10,000 simulations of Sunday's NFL matchup using state-of-the-art AI technology to determine the best Cardinals vs. Panthers bets, player props and predictions.
According to our predictions, the Cardinals will likely win with a projected final score of 25-20.
To get the maximum value from these predictions, we continually monitor the best odds for each market. This ensures that the sportsbooks listed below are currently offering the highest payouts for the specified plays.
Our Cardinals vs. Panthers Betting Picks & Predictions
Today's Cardinals vs. Panthers picks fuse the power of AI, statistics and analytics to create NFL picks that are free from the emotional biases often associated with human-made picks.
Cardinals vs. Panthers Game Information
- Game Date: Sunday, December 22nd, 2024
- Game Time: 1:00 p.m. ET
- Location: Bank of America Stadium
- Spread: Cardinals -5.5 / Panthers +5.5
- Moneyline: Cardinals -245 / Panthers +215
- Scoring Total: Over/Under 46.5 Points (-110/-110)
Panthers +5.5 @ -105 via FanDuel Sportsbook
- According to our simulations, both the Cardinals and Panthers have a 50% chance of covering the spread in this matchup.
- We prefer the Panthers +5.5 based on FanDuel Sportsbook's more favorable odds of -105.
Total Points Over 46.5 @ -110 via FanDuel Sportsbook
- The over/under for total points scored is set at 46.5, with FanDuel Sportsbook offering the best odds for the over at -110.
- Our analysis indicates a 51% likelihood that the total will go over 46.5 points.
Cardinals vs. Panthers Moneyline Odds
The sportsbooks have released the moneyline odds for this matchup, with the Arizona Cardinals at -245 via DraftKings Sportsbook, whilst the Carolina Panthers are available at +215 with FanDuel Sportsbook.
According to the model, the Cardinals are favored to win this game, with our projections assigning them a 68% chance of coming out on top.
Even though the Cardinals are more likely to win, FanDuel Sportsbook offers +215 odds on the Panthers moneyline, providing an edge of 0.2%. This makes it our recommended moneyline bet.
Our Player Prop Picks for Cardinals vs. Panthers
Here, we have outlined the projected player stats for the top offensive players on each team. We have then compared these projections to the odds and lines with the sportsbooks to produce NFL player props for Sunday's Cardinals vs. Panthers matchup.
Arizona Cardinals Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
James Conner | 73 yds | 57% |
Kyler Murray | 44 yds | 40% |
DeeJay Dallas | 20 yds | 13% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Trey McBride | 70 yds | 40% |
Marvin Harrison | 57 yds | 43% |
Michael Wilson | 34 yds | 23% |
James Conner Under 85.5 Rushing Yards (-110)
Pick | Operator | New Users | Odds |
---|---|---|---|
James Conner Under 85.5 Rushing Yards | FanDuel Sportsbook | Get Offer | -110 |
- Our top prop bet for the Cardinals is for James Conner to record under 85.5 rushing yards.
- Our analysis projects this prop to have a probability of 69.5%, giving us an edge of 17.1% on the -110 odds offered by FanDuel.
Carolina Panthers Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Chuba Hubbard | 66 yds | 49% |
Bryce Young | 18 yds | 22% |
Mike Boone | 12 yds | 14% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Adam Thielen | 62 yds | 30% |
Jalen Coker | 47 yds | 27% |
David Moore | 44 yds | 27% |
Chuba Hubbard Under 3.5 Receptions (-115)
Pick | Operator | New Users | Odds |
---|---|---|---|
Chuba Hubbard Under 3.5 Receptions | DraftKings Sportsbook | Get Offer | -115 |
- Our best prop bet for the Panthers is for Chuba Hubbard to record under 3.5 receptions.
- According to our analysis, this prop has a probability of 74.0%, giving us an edge of 20.5% on the -115 odds offered by DraftKings.
These NFL player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.
Cardinals vs. Panthers Betting Trends
In addition to our NFL prop picks, we have sourced the best Cardinals vs. Panthers trends to enhance your research and betting strategy for this game.
Trey McBride Over 68.5 Receiving Yards
Trey McBride has recorded more than 68.5 receiving yards in 5 of his last 5 games (100% success rate). You can bet on him to go over 68.5 receiving yards again at odds of -110 (52% implied probability), available at Bet365.
Kyler Murray Over 223.5 Passing Yards
Kyler Murray has had more than 223.5 passing yards in 5 of his last 5 games (100%). You can make a bet that he'll record over 223.5 passing yards again at odds of -110 (52%), also available at Bet365.
Kyler Murray Over 21.5 Passing Completions
Kyler Murray has had more than 21.5 passing completions in 5 of his last 5 appearances (100%). You can bet on him to record over 21.5 passing completions again at odds of +108 (48%), available at FanDuel.
Conclusion
At BettingOdds.com, we're backing Chuba Hubbard of the Panthers to record Receptions 3.5 receptions, with an edge of 20.5% marking this as our top prop bet of the game. Additionally, we're placing a bet on the Panthers +5.5 to cover.
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