Broncos vs. Bills Picks & Best Bets 12th Jan 2025: NFL Week 19 Prediction, Betting Odds, Player Props & Trends

The Buffalo Bills will take on the Denver Broncos in NFL action on Sunday at Highmark Stadium, starting at 1:00 p.m. ET.
We have conducted 10,000 simulations of Sunday's NFL matchup using state-of-the-art AI technology to determine the best Broncos vs. Bills bets, player props and predictions.
Our predictions show that the Bills will likely win with a projected final score of 27-20.
To maximize the value of predictions like this, we constantly monitor the best odds for each market. This ensures that the sportsbooks listed below are currently offering the biggest payouts for the plays identified.
Our Broncos vs. Bills Betting Picks & Predictions
Today's Broncos vs. Bills picks combine the power of AI, data and analytics to produce NFL predictions that are free from the emotional biases often associated with human-made picks.
Broncos vs. Bills Game Information
- Game Date: Sunday, January 12th, 2025
- Game Time: 1:00 p.m. ET
- Location: Highmark Stadium
- Spread: Broncos +8 / Bills -8
- Moneyline: Broncos +350 / Bills -440
- Scoring Total: Over/Under 49.5 Points (-105/-115)
Broncos +8 @ -110 via BetMGM
- According to our simulations, the Broncos have a 60% chance of covering the spread, while the Bills have a probability of 40%.
- BetMGM offers odds of -110 for the Broncos +8, providing a favorable 7.6% edge for them to cover.
Total Points Under 49.5 @ -115 via DraftKings Sportsbook
- The over/under for total points scored is set at 49.5 at DraftKings Sportsbook, which offers the best odds for the under at -115.
- Our analysis indicates a 52% likelihood that the total will stay under 49.5 points.
Broncos vs. Bills Moneyline Odds
The sportsbooks have released the moneyline odds for this matchup, with the Denver Broncos at +350 via BetMGM, whilst the Buffalo Bills are available at -440 with DraftKings Sportsbook.
According to the model, the Bills are favored to win this game, with our projections assigning them a 72% chance of victory.
Even though the Bills are more likely to win, BetMGM offers +350 odds on the Broncos moneyline, providing an edge of 5.5%. This makes it our recommended moneyline bet.
Our Player Prop Picks for Broncos vs. Bills
Here, we have outlined the projected player stats for the top offensive players on each team. We have then compared these projections to the odds and lines with the sportsbooks to produce NFL player props for Sunday's Broncos vs. Bills game.
Denver Broncos Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Jaleel McLaughlin | 43 yds | 29% |
Audric Estime | 23 yds | 21% |
Bo Nix | 21 yds | 22% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Courtland Sutton | 62 yds | 43% |
Marvin Mims | 45 yds | 27% |
Devaughn Vele | 33 yds | 23% |
Bo Nix Under 29.5 Rushing Yards (-110)
Pick | Operator | New Users | Odds |
---|---|---|---|
Bo Nix Under 29.5 Rushing Yards | FanDuel Sportsbook | Get Offer | -110 |
- Our top prop bet for the Broncos is for Bo Nix to record under 29.5 rushing yards.
- Our analysis projects this prop to have a probability of 78.3%, giving us an edge of 25.9% on the -110 odds offered by FanDuel.
Buffalo Bills Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
James Cook | 66 yds | 49% |
Josh Allen | 40 yds | 50% |
Ray Davis | 20 yds | 14% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Khalil Shakir | 57 yds | 31% |
Amari Cooper | 42 yds | 26% |
Dalton Kincaid | 38 yds | 20% |
Josh Allen Under 44.5 Rushing Yards (-110)
Pick | Operator | New Users | Odds |
---|---|---|---|
Josh Allen Under 44.5 Rushing Yards | DraftKings Sportsbook | Get Offer | -110 |
- Our best prop bet for the Bills is for Josh Allen to record under 44.5 rushing yards.
- According to our analysis, this prop has a probability of 69.6%, giving us an edge of 17.2% on the -110 odds offered by DraftKings.
These NFL player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.
Broncos vs. Bills Betting Trends
In addition to our NFL prop picks, we have sourced the best Broncos vs. Bills trends to enhance your research and betting strategy for this game.
Nate Adkins Over 3.5 Receiving Yards
Nate Adkins has recorded more than 3.5 receiving yards in 5 of his last 5 appearances (100% of the time). You can wager on him to go over 3.5 receiving yards again at odds of -110 (52% implied probability), available at Bet365.
Marvin Mims Jr. Over 40.5 Receiving Yards
Marvin Mims Jr. has had more than 40.5 receiving yards in 6 of his last 7 games (86%). You can place a bet on him to record over 40.5 receiving yards again at odds of -110 (52%), also available at Bet365.
Lil'Jordan Humphrey Over 0.5 Receiving Yards
Lil'Jordan Humphrey has recorded at least one receiving yards in 9 of his last 10 appearances (90%). You can wager on him to record at least one more again at odds of -110 (52%), again available at Bet365.
Conclusion
At BettingOdds.com, we're backing Bo Nix of the Broncos to record Rushing Yards 29.5 rushing yards, with an edge of 25.9% marking this as our top prop bet of the game. Additionally, we're betting on the Broncos +8 to cover.
Beyond our Broncos vs. Bills predictions, we offer extensive NFL betting tools. These include the latest NFL odds tonight and insightful NFL predictions for today to elevate your betting game. Discover top picks with our NFL best bets and dive into NFL sports journalists' insights. Plus, find the best odds and promotions with our guide to the best NFL betting sites.