49ers vs. Rams Picks & Best Bets 22nd Sep 2024: NFL Week 3 Prediction, Betting Odds, Player Props & Trends

The Los Angeles Rams will take on the San Francisco 49ers in NFL action on Sunday at SoFi Stadium, starting at 4:25 p.m. ET.

We performed 10,000 simulations of Sunday's NFL matchup using innovative AI technology to identify the best 49ers vs. Rams bets, player props and predictions.

Based on these simulations, we predict that the 49ers will likely beat the Rams with a projected final score of 25-19.

To maximize the value of predictions like this, we continuously source the most favorable odds for each market. This means that the sportsbooks listed below are currently offering the biggest payouts for the plays identified.

Our 49ers vs. Rams Betting Picks & Predictions

Today's 49ers vs. Rams picks fuse the power of AI, data and analytics to generate NFL predictions that are free from the emotional biases often associated with human-made picks.

49ers vs. Rams Game Information

• Game Date: Sunday, September 22nd, 2024
• Game Time: 4:25 p.m. ET
• Location: SoFi Stadium
• Spread: 49ers -6.5 / Rams +6.5
• Moneyline: 49ers -258 / Rams +230
• Scoring Total: Over/Under 44.5 Points (-108/-110)

Rams +6.5 @ -122 via FanDuel Sportsbook

• According to our simulations, the Rams have a 55% chance of covering the spread, while the 49ers have a probability of 45%.
• FanDuel Sportsbook offers odds of -122 for the Rams +6.5, presenting a favorable 0.5% edge for them to cover.

Total Points Over 44.5 @ -108 via DraftKings Sportsbook

• The over/under for total points scored is set at 44.5, with DraftKings Sportsbook offering the best odds for the over at -108.
• Our analysis suggests a slightly higher likelihood that the total will go over 44.5 points.

49ers vs. Rams Moneyline Odds

The sportsbooks have released the moneyline odds for this matchup, with the San Francisco 49ers at -258 via DraftKings Sportsbook, whilst the Los Angeles Rams are available at +230 with FanDuel Sportsbook.

According to the model, the 49ers are favored to win this game, with our projections assigning them a 69% chance of victory.

Although the 49ers are more likely to win, FanDuel Sportsbook offers +230 odds on the Rams moneyline, providing an edge of 0.2%. This makes it our recommended moneyline bet.

Our Player Prop Picks for 49ers vs. Rams

Here, we have outlined the projected player stats for the top offensive players on each team. We have then compared these projections to the odds and lines with the sportsbooks to produce NFL player props for Sunday's 49ers vs. Rams game.

San Francisco 49ers Prediction

Kyle Juszczyk Under 18.5 Receiving Yards (-110)

• Our top prop bet for the 49ers is for Kyle Juszczyk to record under 18.5 receiving yards.
• Our analysis projects this prop to have a probability of 77.1%, giving us an edge of 24.7% on the -110 odds offered by FanDuel.

Los Angeles Rams Prediction

Kyren Williams Under 3.5 Receptions (-135)

• Our best prop bet for the Rams is for Kyren Williams to record under 3.5 receptions.
• According to our analysis, this prop has a probability of 85.0%, providing an edge of 27.5% on the -135 odds offered by DraftKings.

These NFL player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.

Conclusion

At BettingOdds.com, we're backing Kyren Williams of the Rams to record Receptions 3.5 receptions, with an edge of 27.5% marking this as our top prop bet of the game. Additionally, we're placing a bet on the Rams +6.5 to cover.

In addition to our 49ers vs. Rams predictions, we offer a wide range of NFL betting resources. These include the latest NFL odds and insightful NFL expert picks to elevate your betting game. Discover top picks with the NFL best bets today and dive into our NFL expert insights. Plus, find the best odds and promotions with our guide to the best NFL betting sites.