49ers vs. Cardinals Picks & Best Bets 5th Jan 2025: NFL Week 18 Prediction, Betting Odds, Player Props & Trends

The Arizona Cardinals will go up against the San Francisco 49ers in NFL action on Sunday at State Farm Stadium, starting at 4:25 p.m. ET.
We performed 10,000 simulations of Sunday's NFL matchup using innovative AI technology to determine the best 49ers vs. Cardinals bets, player props and predictions.
According to our predictions, the Cardinals will likely defeat the 49ers with a projected final score of 23-19.
To maximize the value of predictions like this, we continuously source the most favorable odds for each market. This ensures that the sportsbooks listed below are currently offering the biggest payouts for the plays identified.
Our 49ers vs. Cardinals Betting Picks & Predictions
Today's 49ers vs. Cardinals picks fuse the power of AI, data and analytics to produce NFL picks that are free from the emotional biases often associated with human-made picks.
49ers vs. Cardinals Game Information
- Game Date: Sunday, January 5th, 2025
- Game Time: 4:25 p.m. ET
- Location: State Farm Stadium
- Spread: 49ers +4.5 / Cardinals -4.5
- Moneyline: 49ers +190 / Cardinals -192
- Scoring Total: Over/Under 42.5 Points (-105/-110)
49ers +4.5 @ -106 via FanDuel Sportsbook
- According to our simulations, both the 49ers and Cardinals have a 50% chance of covering the spread in this matchup.
- We prefer the 49ers +4.5 due to FanDuel Sportsbook's more favorable odds of -106.
Total Points Over 42.5 @ -105 via FanDuel Sportsbook
- The over/under for total points scored is set at 42.5, with FanDuel Sportsbook offering the best odds for the over at -105.
- Our analysis indicates a slightly higher chance of the 42.5-point total going over.
49ers vs. Cardinals Moneyline Odds
The sportsbooks have released the moneyline odds for this matchup, with the San Francisco 49ers at +190 via FanDuel Sportsbook, whilst the Arizona Cardinals are available at -192 with DraftKings Sportsbook.
According to the model, the Cardinals are favored to win this game, with our projections assigning them a 67% chance of prevailing.
Not only are they favored to win, but the Cardinals also present the best betting value, with the odds of -192 available at DraftKings Sportsbook for an edge of 1.5%.
Our Player Prop Picks for 49ers vs. Cardinals
Here, we have outlined the projected player stats for the top offensive players on each team. We have then compared these projections to the odds and lines with the sportsbooks to produce NFL player props for Sunday's 49ers vs. Cardinals game.
San Francisco 49ers Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Isaac Guerendo | 79 yds | 46% |
Joshua Dobbs | 34 yds | 23% |
Patrick Taylor | 10 yds | 8% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Jauan Jennings | 67 yds | 37% |
George Kittle | 56 yds | 37% |
Ricky Pearsall | 40 yds | 26% |
Jauan Jennings Under 80.5 Receiving Yards (-120)
Pick | Operator | New Users | Odds |
---|---|---|---|
Jauan Jennings Under 80.5 Receiving Yards | DraftKings Sportsbook | Get Offer | -120 |
- Our top prop bet for the 49ers is for Jauan Jennings to record under 80.5 receiving yards.
- Our analysis projects this prop to have a probability of 65.5%, providing an edge of 11.0% on the -120 odds offered by DraftKings.
Arizona Cardinals Prediction
Player | Proj. Rush Yds | TD Prob. |
---|---|---|
Michael Carter | 62 yds | 46% |
Kyler Murray | 43 yds | 40% |
DeeJay Dallas | 17 yds | 12% |
Player | Proj. Rec Yds | TD Prob. |
---|---|---|
Trey McBride | 72 yds | 42% |
Marvin Harrison | 54 yds | 39% |
Michael Wilson | 33 yds | 21% |
Kyler Murray Under 44.5 Rushing Yards (-110)
Pick | Operator | New Users | Odds |
---|---|---|---|
Kyler Murray Under 44.5 Rushing Yards | FanDuel Sportsbook | Get Offer | -110 |
- Our best prop bet for the Cardinals is for Kyler Murray to record under 44.5 rushing yards.
- According to our analysis, this prop has a probability of 60.5%, giving us an edge of 8.1% on the -110 odds offered by FanDuel.
These NFL player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.
49ers vs. Cardinals Betting Trends
In addition to our NFL prop picks, we have sourced the best 49ers vs. Cardinals trends to enhance your research and betting strategy for this matchup.
George Kittle Over 46.5 Receiving Yards
George Kittle has recorded more than 46.5 receiving yards in 9 of his last 10 games (90% of the time). You can put money on him to record 47+ receiving yards again at odds of -110 (52% implied probability), available at Bet365.
Joshua Dobbs Over 18.5 Passing Completions
Joshua Dobbs has had more than 18.5 passing completions in 7 of his last 9 appearances (78%). You can make a bet that he'll record over 18.5 passing completions again at odds of +100 (50%), available at DraftKings.
Conclusion
At BettingOdds.com, we're backing Jauan Jennings of the 49ers to record Receiving Yards 80.5 receiving yards, with an edge of 11% marking this as our top prop bet of the game. Additionally, we're placing a bet on the 49ers +4.5 to cover.
Beyond our 49ers vs. Cardinals predictions, we offer a wide range of NFL betting tools. These include the latest NFL odds tonight and insightful NFL predictions today to elevate your betting game. Discover top picks with the NFL best bets today and dive into Kyle Odegard's NFL insights. Plus, find the best odds and promotions with our guide to the top NFL betting sites.