NFL Best Bets & Expert Picks for Today 22nd September 2024

It's time for football on Sunday, September 22, with 13 regular-season NFL games that we can bet on today.

Our predictive analytics model has simulated the outcome of each game and identified the top five betting opportunities, with the best bet of the day coming in the Chargers vs. Steelers matchup at 1:00PM ET.

We're also placing wagers on the Texans vs. Vikings and Packers vs. Titans, making for an exciting Sunday for NFL betting.

NFL Best Bets for Today

Sunday's NFL action features five bets with a betting edge according to our model. The best value is Chargers +2.5, offering an edge of 5.8% at odds of -110.

Top NFL Picks for 22nd September 2024

Prepare for an exhilarating day of football action with our top picks for 22nd September 2024. These plays offer valuable opportunities for success, based on precise data analysis and predictive algorithms.

Having analyzed every spread, total and moneyline, each pick is meticulously chosen to offer an edge in today's football matchups.

Elevate your Sunday betting experience with these expertly curated predictions that are free from the emotional biases often associated with human-made picks.

Chargers +2.5 (-110)

• Chargers vs. Steelers (1:00PM ET, Sunday)
• 5.8% edge
• 58.2% probability
• Best odds available with BetMGM

With a calculated edge of 5.8% and a probability of 58.2%, the Chargers +2.5 spread bet at -110 is our top pick for today's football. Don't miss this value bet in the Chargers vs. Steelers matchup at 1:00PM ET, available at BetMGM.

Texans ML (-125)

• Texans vs. Vikings (1:00PM ET, Sunday)
• 4.6% edge
• 60.1% probability
• Best odds available with BetMGM

With a strong probability of 60.1% and an edge of 4.6%, the Texans ML bet at -125 is another strong play. Place your bet on this +EV pick in the Texans vs. Vikings game before it begins at 1:00PM ET, with the best odds available at BetMGM.

Titans ML (-142)

• Packers vs. Titans (1:00PM ET, Sunday)
• 3.5% edge
• 62.2% probability
• Best odds available with DraftKings Sportsbook

Offering an edge of 3.5% and a significant probability of 62.2%, the Titans ML bet at -142 with DraftKings Sportsbook is our next recommended bet for today's NFL. Don't let these odds pass by in the Packers vs. Titans matchup at 1:00PM ET.

Cardinals +3 (-114)

• Lions vs. Cardinals (4:25PM ET, Sunday)
• 3.2% edge
• 56.5% probability
• Best odds available with FanDuel Sportsbook

Today's fourth pick is Cardinals +3 at -114, with a probability of 56.5% and an edge of 3.2%. Take advantage of this top betting chance in the Lions vs. Cardinals matchup at 4:25PM ET, available at FanDuel Sportsbook.

Rams +6.5 (-110)

• 49ers vs. Rams (4:25PM ET, Sunday)
• 3.1% edge
• 55.5% probability
• Best odds available with BetMGM

Our NFL analysis highlights the Rams +6.5 spread at -110 as another +EV wager, backed by an edge of 3.1% and a 55.5% chance of hitting. Jump on this promising wager in the 49ers vs. Rams game at 4:25PM ET, available at BetMGM.

Best NFL Parlay for Sunday

Sunday's NFL parlay consists of three legs, offering odds of +556 at BetMGM.

Conclusion

At BettingOdds.com, our NFL play of the day is the Chargers to cover the +2.5 spread. Additionally, we have four further bets and a +556 parlay, offering value for those seeking data-driven bets on today's football games.

In addition to our Sunday NFL best bets and parlay, we offer extensive NFL betting tools. These include the latest NFL odds and insightful NFL predictions for today to elevate your betting game. Discover top picks with our best NFL bets tonight and dive into our NFL insights. Plus, find the best odds and promotions with our guide to the best NFL betting sites.