Steelers vs. Bills 2021 Predictions: Pittsburgh could be in line for the big road upset

Father Time and Ben Roethlisberger are surely going to meet at some point soon but going into Week 1, Neil Monnery thinks we have no idea whether they've had any interaction yet...
Heading into the 2021 season, one of the teams that feel like a complete unknown to me is the Pittsburgh Steelers. This seems funky considering the offense is returning most of the same players but I just do not have a good feel for how Ben Roethlisberger will play in this upcoming season.
Whilst Father Time has seemingly lost Tom Brady’s address, he found Peyton Manning, he found Drew Brees and I’m sure he’s in his car looking for where Big Ben resides. Whether he’s going to turn up this season or not though is just a big question mark in my mind at this juncture.
Donate Johnson, JuJu Smith-Schuster and Chase Claypool can all play. Eric Ebron is athletic but has a history of a case of the dropsies but how will rookie Najee Harris do as the top option in the backfield?
On Sunday though they travel to Buffalo who have far fewer concerns heading into the 2021 season. Josh Allen proved last year that he’s the real deal who has a rocket arm and can get it done on the ground as well. Stefon Diggs is a known commodity at receiver and the addition of Emmanuel Sanders will give an added option to go along with the reliable Cole Beasley.
I do like the Bills but this feels like a really tough opening game and I smell a whiff of an upset...
Spread:
The Bills are the 6.5pt favorites and I think that how to bet this market is all about how you feel Ben Roethlisberger will play. I just have a funny feeling that we might get one final big year out of the future HoF QB. I think this game is close so give me Pittsburgh and the points.
Straight-up/Moneyline:
You can get -286 on Pittsburgh winning straight up and boy that tempts me. This is the best time to believe in the Steelers as they will be as healthy as they can get. I think this is one of those occasions where taking the underdog straight up isn’t a bad move. Give me Pittsburgh!
Over/Under Points Totals:
The over/under number has been set at 48.5 and I feel pretty confident both teams can get into the 20s on Sunday which enhances the chances the over wins here. I’m happy to take the over.