Guardians vs. Cardinals Picks & Best Bets 22nd Sep 2024: MLB Prediction, Betting Odds, Player Props & Trends

The St. Louis Cardinals will take on the Cleveland Guardians in MLB action on Sunday at Busch Stadium, starting at 2:15 p.m. ET.

We performed 10,000 simulations of Sunday's MLB matchup using cutting-edge AI technology to determine the best Guardians vs. Cardinals bets, player props and predictions.

According to our predictions, the Cardinals have a 53% chance of beating the Guardians.

To maximize the value of predictions like this, we continually monitor the most favorable odds for each market. This ensures that the sportsbooks listed below are currently offering the highest payouts for the specified plays.

Our Guardians vs. Cardinals Betting Picks & Predictions

Today's Guardians vs. Cardinals picks combine the power of AI, data and analytics to produce MLB predictions that are free from the emotional biases often associated with human-made picks.

Guardians vs. Cardinals Game Information

• Game Date: Sunday, September 22nd, 2024
• Game Time: 2:15 p.m. ET
• Location: Busch Stadium
• Run Line: Guardians +1.5 / Cardinals -1.5
• Moneyline: Guardians +110 / Cardinals -125
• Scoring Total: Over/Under 7.5 Runs (-105/-110)

Guardians +1.5 @ -192 via DraftKings Sportsbook

• According to our simulations, the Guardians have a 66% chance of covering the run line, while the Cardinals have a probability of 34%.
• DraftKings Sportsbook offers the best odds for this bet at -192.

Total Runs Over 7.5 @ -105 via DraftKings Sportsbook

• The over/under for total runs scored is set at 7.5 at DraftKings Sportsbook, which offers the best odds for the over at -105.
• Our analysis indicates a 56% chance that the total will go over 7.5 runs, providing an edge of 4.5%.

Guardians vs. Cardinals Moneyline Odds

The sportsbooks have released the moneyline odds for this matchup, with the Cleveland Guardians at +110 via DraftKings Sportsbook, whilst the St. Louis Cardinals are available at -125 with BetMGM.

According to the model, the Cardinals are favored to win this game, with our projections giving them a 53% chance of victory.

Even though the Cardinals are more likely to win, DraftKings Sportsbook offers +110 odds on the Guardians moneyline, making it our recommended moneyline bet, as it represents the best value currently available.

Cleveland Guardians Prediction - Gavin Williams Over 5.5 Strikeouts (+120)

• Our top prop bet for the Guardians is on Gavin Williams to record over 5.5 strikeouts.
• Our analysis projects this prop to have a probability of 59.3%, giving us an edge of 13.8% on the +120 odds offered by BetMGM.

St. Louis Cardinals Prediction - Gavin Williams Over 5.5 Strikeouts (+120)

• Our best prop bet for the Cardinals is on Gavin Williams to have over 5.5 strikeouts.
• According to our analysis, this prop has a probability of 59.3%, giving us an edge of 13.8% on the +120 odds available at BetMGM.

These MLB player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.

Guardians vs. Cardinals Betting Trends

In addition to our MLB prop picks, we have compiled the best Guardians vs. Cardinals trends to enhance your research and betting strategy for this matchup.

José Ramírez to Record a Hit

José Ramírez has recorded at least one hit in 13 of his last 14 games (93% of the time). You can bet on him to do it again at odds of -240 (71% implied probability), available at DraftKings.

Lane Thomas to Hit a Home Run

Lane Thomas has hit at least one home run in 5 of his last 15 appearances (33%). You can make a bet that he'll hit another one at odds of +700 (12%), available at Bet365.

Matt Carpenter to Hit a Home Run

Matt Carpenter has hit at least one home run in 2 of his last 16 games (12%). You can wager on him to homer again at odds of +700 (12%), again available at Bet365.

Conclusion

At BettingOdds.com, we're backing Gavin Williams of the Guardians to record over 5.5 strikeouts, with an edge of 13.8% marking this as our top prop bet of the game. Additionally, we are betting on the Guardians +1.5 to cover.

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