Guardians vs. Cardinals Picks & Best Bets 21st Sep 2024: MLB Prediction, Betting Odds, Player Props & Trends

The St. Louis Cardinals will meet the Cleveland Guardians in MLB action on Saturday at Busch Stadium, starting at 7:15 p.m. ET.

We conducted 10,000 simulations of Saturday's MLB matchup using cutting-edge AI technology to pinpoint the best Guardians vs. Cardinals bets, player props and predictions.

Based on these simulations, we predict that the Guardians have a 54% chance of defeating the Cardinals.

To maximize the value of predictions like this, we constantly source the best odds for each market. This ensures that the sportsbooks listed below are currently offering the highest payouts for the specified plays.

Our Guardians vs. Cardinals Betting Picks & Predictions

Today's Guardians vs. Cardinals picks fuse the power of AI, statistics and analytics to produce MLB predictions that are free from the emotional biases often associated with human-made picks.

Guardians vs. Cardinals Game Information

• Game Date: Saturday, September 21st, 2024
• Game Time: 7:15 p.m. ET
• Location: Busch Stadium
• Run Line: Guardians -1.5 / Cardinals +1.5
• Moneyline: Guardians -130 / Cardinals +110
• Scoring Total: Over/Under 7.5 Runs (-108/-102)

Cardinals +1.5 @ -155 via DraftKings Sportsbook

• According to our simulations, the Cardinals have a 59% chance of covering the run line, while the Guardians have a probability of 41%.
• DraftKings Sportsbook offers the best odds for this bet at -155.

Total Runs Over 7.5 @ -108 via DraftKings Sportsbook

• The over/under for total runs scored is set at 7.5 at DraftKings Sportsbook, which offers the best odds for the over at -108.
• Our analysis shows a 58% likelihood of the 7.5-run total going over, providing an edge of 6.2%.

Guardians vs. Cardinals Moneyline Odds

The sportsbooks have released the moneyline odds for this matchup, with the Cleveland Guardians at -130 via BetMGM, whilst the St. Louis Cardinals are available at +110 with BetMGM.

According to the model, the Guardians are favored to win this game, with our projections giving them a 54% chance of victory.

Even though the Guardians are more likely to win, BetMGM offers +110 odds on the Cardinals moneyline, making it our recommended moneyline bet, as it represents the best value currently available.

Cleveland Guardians Prediction - Matthew Boyd Over 2.5 Earned Runs (+125)

• Our top prop bet for the Guardians is on Matthew Boyd to record over 2.5 earned runs.
• Our analysis projects this prop to have a probability of 57.2%, providing an edge of 12.7% on the +125 odds offered by DraftKings.

St. Louis Cardinals Prediction - Matthew Boyd Over 2.5 Earned Runs (+125)

• Our best prop bet for the Cardinals is on Matthew Boyd to have over 2.5 earned runs.
• According to our analysis, this prop has a probability of 57.2%, providing an edge of 12.7% on the +125 odds available at DraftKings.

These MLB player props today are based purely on advanced modeling techniques that factor in variables including but not limited to past form and opponent trends, meaning you can trust that there is no bias that comes into play.

Guardians vs. Cardinals Betting Trends

In addition to our MLB prop picks, we have sourced the best Guardians vs. Cardinals trends to enhance your research and betting strategy for this matchup.

Bo Naylor to Hit a Home Run

Bo Naylor has hit at least one home run in 3 of his last 21 games (14% success rate). You can put money on him to do it again at odds of +600 (14% implied probability), available at Bet365.

Conclusion

At BettingOdds.com, we're backing Matthew Boyd of the Guardians to record over 2.5 earned runs, with an edge of 12.7% marking this as our top prop bet of the game. Additionally, we are placing a bet on the Cardinals +1.5 to cover.

In addition to our Guardians vs. Cardinals predictions, we offer a wide range of MLB betting tools. These include the latest MLB odds for today and insightful MLB predictions today to elevate your betting game. Discover top picks with the MLB best bets today and dive into our MLB insights. Plus, find the best odds and promotions with our guide to the top online MLB betting sites.