Best March Madness Parlay Bet Today: Marquette, Purdue, Duke, Creighton Sweet 16 Wager at +1111 odds

Half of the Elite Eight field is set. The other half will be determined on Friday.

We have four pretty good matchups, and it’s time to dissect which quartet will advance.

I’ve made my projections, and by combining them into a parlay, a payout of +1111 odds awaits over at BetMGM if they all hit.

Check below for the moneyline betting picks and the rationale for the Sweet 16 tournament plays on Friday.

Moneyline bets: Marquette (-300) vs. North Carolina State; Purdue (-250) vs. Gonzaga; Duke (+165) vs. Houston; Creighton (+145) vs. Tennessee 
Parlay odds: +1111 at BetMGM

Leg 1: Marquette (-300) defeats North Carolina State

• North Carolina State is a No. 11 seed and has a ranking of just No. 53 per KenPom, easily the worst remaining in the field
• Marquette is top-20 in efficiency on both offense and defense, and that balance should help the Eagles pull away
• The Wolfpack have definitely gotten hot in the ACC Tournament and now March Madness, but the overall body of work suggests an exit here in the Sweet 16

Leg 2: Purdue (-200) defeats Gonzaga

• Purdue has the No. 3 offense in the country while Gonzaga is middling on defense
• It’s hard to imagine the Zags can control Zach Edey, who is averaging 26.5 points, 17.5 rebounds and three blocks per game in the tournament

Leg 3: Duke (+165) defeats Houston

• The Cougars are the rightful favorites but this moneyline offer is too good to pass up
• While Houston is No. 3 in the nation in KenPom efficiency, the Blue Devils are right behind them at No. 5
• Houston has shown some vulnerability of late, with a blowout loss to Iowa State in the Big 12 conference tournament and a game that went to overtime against Texas A&M in the Round of 32

Leg 4: Creighton (+145) defeats Tennessee

• If we make it this far, Creighton will need to finish off this men's college basketball parlay as the 3.5-point underdog
• Tennessee is No. 8 in team efficiency, per KenPom, but Creighton is right behind at No. 11, making this a worthy upset play
• The Volunteers are just 30th in the country in offensive efficiency, while Creighton is top-10